Connective Tissue Health Blog, updated August 11, 2018

Supplements for connective tissue regeneration, Carpal Tunnel Syndrome, and even regrowing the pads between the disks of the spine.
By Chris Steiner

* Amino acids: L-Arginine or even better at boosting nitric oxide that dilates blood vessels is precursor, L-Citrulline; L-Glycine; L-Proline
* Cetyl Myristoleate (CMO)
* Chondroitin sulfate and glucosamine sulfate (sometimes not enough to make a noticeable difference without other supplements)
* Collagen types 2 or 3
* Colostrum (from New Zealand or other clean source of humanely-treated cows): I prefer 21st Century brand
* EFAs: essential fatty acids like what's in hemp seed oil, which I take, or a high quality fish oil: strong anti-inflammatories and mood lifters
* Hyaluronic acid (usually expensive so can be sourced from Kombucha culture)
* Magnesium, preferably in the form of sulfate (Esom Salt), a good sulfur source; other good forms are citrate, ascorbate, malate, glycinate, or aspartate; avoid magnesium oxide as it's oxidized, free radical-inducing
* Methyl Sulfonyl Methane (MSM): good sulfur source
* Mixed nucleotides
* N-Acetyl D-Glucosamine
* Organic bone broth soup
* Serrapeptase
* Shark cartilage
* Silicon (collagen precursor; sources: bamboo, food-grade diatomaceous earth, horsetail, nettle leaf, oat straw, seaweeds (I would avoid because of contaminants from the sea such as mercury and Fukushima radioactive isotopes); and beware horsetail: http://medcapsules.com/info/Silica_Diatomaceous%20Earth%20vs%20Horsetail%20Grass.htm)
* Vitamin C (collagen precursor) from food sources, not isolated ascorbic acid / ascorbate supplements
* Vitamin D3 (2,000 to 5,000 IU/day or more depending on nutritional blood analysis)

Strong anti-inflammatories to increase healing and provide comfort (if you don't like hot foods you can take the hot items in capsule form):
* Andrographis (Andrographis paniculata)
* Boswellia (Boswellia serrata) and its oil, frankincense 
* Bromelain (from pineapple)
* Cayenne and other hot peppers
* Devil's claw (Harpagophytum procumbens, Harpagophytum zeyheri)
* Ginger root
* Nattokinase
* Turmeric or Curcumin (turmeric extract)
* Applied topically: organic, therapeutic- (medicinal-) grade essential oils of Rosemary, Eucalyptus, Arnica, and Turmeric.  To prevent skin drying mix with a carrier oil, preferably coconut or macadamia as they're rich in Omega-7 fatty acids found in skin.  Organic brands of essential oils are best.
     For my daily EFAs (essential fatty acids) I take a big swallow of organic hemp seed oil that I buy in the refrigerated supplement section at a local health store, Nature's Food Patch, for a great value.  Doing this, my EFA levels are good per nutritional blood test.  For fat/EFA (essential fatty acid), emulsification, absorption, and metabolism take any or all of these before eating:
* Acetyl L-Carnitine transports fats across cell membranes to be metabolized by the mitochondria for energy.
* Alpha Lipoic Acid or, even better, R-Fraction Alpha Lipoic Acid, antioxidants that are both fat- and water-soluble.
* Bile salts
* D-Limonene
* Lipase
* Raw, organic apple cider vinegar (Bragg's brand I like) after meals. For vinegar I also drink home-brewed Kombucha. The tighter the batch is sealed, the more vinegar is made. But Kombucha shouldn't be completely sealed lest offgassing burst its container.
* Sunflower seed lecithin (avoid soy- and soya-source lecithin)
* Possibly Garcinia Cambogia based on anecdotes
     Many aren't just Omega 3-deficient, but neither can they absorb other EFAs in order to produce balanced hormones, neurotransmitters, skin, hair, nails, connective tissue, and much more.  My preferred source is a big swallow of organic hemp seed oil daily as my blood EFA levels are healthy.
     Plus as a multi-mineral you may want Microcrystalline Hydroxyapatite (MCHA / MCHC) that can increase bone density and mass up to 30% per year, a claim made by the originator, Ethical Nutrients, maker of Bone Builder, and authorized by the FTC after a long legal battle (ftc.gov/sites/default/files/documents/cases/1996/10/d9267idc.pdf). No pharmaceutical drug nor any other form of calcium can come close.  Calcium citrate is the only other form of which I know that can improve bone density and mass, but only up to 3% per year.  Other forms, including calcium carbonate (chalk) so commonly sold, prevent bone loss by keeping calcium levels up in the blood, but don't rebuild bone. The MCHA I take is Now Foods' Bone Strength, 240 capsules (the best value of which I know is at https://iherb.com/pr/Now-Foods-Bone-Strength-240-Capsules/437) because it's a good deal, the cow bone from which the MCHA is derived is from New Zealand where the environment is cleaner and the cows are raised more humanely; plus it includes many other nutrients that help bone health and the formula acts as a somewhat comprehensive multi-mineral.  After 20+ of taking MCHA in various products, my dental X-rays show I have great bone density.  Prosthetics and [dental] implants are coated with MCHA to speed mending and integration (http://en.wikipedia.org/wiki/Hydroxylapatite).  A friend who broke her femur was diagnosed with severe osteoporosis, began taking three capsules per day of Swanson's Bone Building Formula with boron (no longer available), and a year later amazed her doctor when she was then diagnosed with only mild osteopenia (mild thinning of bones).

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Connective Tissue & Raisin Bread
By Ben Fuchs
Source: http://pharmacistben.com/health/connective-tissue-raisin-bread
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SUMMARY
-Connective tissue is one of 4 main tissues in the body.  The others are nerve, muscle and epithelial tissue.
-Connective tissue is made up of cells and a matrix that is akin the raisins and bread.
-Most significant connective tissue cells are called blast cells and the manufacture the connective tissue matrix they are embedded in.
-These blast produced substances are fibers which provide structural support and polysaccharides that function as shock absorbers.
-Many health issues such as autoimmunity are manifestations of connective tissue breakdown.  So are the general signs of aging including bone fragility, muscle weakness, wrinkles, and thinning skin.
The human body is made up of 4 systems.  Biologist’s call these systems “tissues”, they’re made up of cells and they in turn comprise everything that makes up a living body.  These tissue systems include nerve tissue which forms the nervous system, epithelial tissue which forms skin hair, nails, glands and all surfaces, skin and within and muscle tissue which makes up the muscular substance of the body.
Connective Tissue & Raisin BreadThe 4th and most abundant tissue system is called connective tissue (CT) and boy is this stuff cool.  Connective tissue is not only the most abundant tissue in the human body, it’s the most abundant biological tissue on the planet.  In a sense connective tissue is like raisin bread.  It’s made up cells and “stuff” which can be thought of as analogous to raisins (cells) and bread (“stuff”).  Of course in the body we have various types of raisins/cells and a matrix that is much more complex then bread, still, simplistic as it may be, this practical kitchen pantry visual can give a rough idea of the structure of connective tissue.
Of the numerous types of cells in connective tissue by far the most important are the blast cells, which are responsible for the manufacturing of connective tissue.  These cells are called by various names, depending on where in the body they’re found.  The prototypical connective tissue blast cell is called the fibroblast. The fibroblasts are the connective tissue workhorse cells.  They produce fibers that keep epithelial and muscle tissues strong, elastic and well supported and slimy mucus-like substances called polysaccharides.  The only tissue system that does not include connective is the nervous system. While surrounded with CT on its perimeter the nervous system as its own specialized version of CT called “glia”.
Connective tissue can be though as matrix that holds the body’s structures and organs in place.  Because the vast majority of the body is connective tissue, understanding what it is and how to maintain its strength integrity is critical for keeping the body healthy and vital.  The aging process is largely marked by accelerated breakdown and sluggish repair of connective tissue.  And because connective is derived from processes that occur in blasts, feeding and nourishing and as well as detoxifying these critical hard working manufacturing cells is job #1 for healing, repair and anti-aging.
As noted above, connective tissue blast cells produce two major classes of substances that form the bread/matrix that they, in raisin-like fashion are embedded in.   Biologist’s call these two substances fiber and slime. OK, not really.  The fiber component is made up of what is called collagen along with some elastin and a smattering of a third substance called reticulin.  The gooey slimy substance is called polysaccharide whose wet mucoid nature is a manifestation of its high water absorbing capacity.  The slimy nature of polysaccharide water-trapping properties allows it function as very efficient biological shock absorber.
For most connective tissues the fibers predominate, but in the case of a very specialized type of connective tissue, fibers are scarce (or they should be, a harbinger of a disease and an early demise  is  an excessive amount of blood fiber formation) and the wet polysaccharides rule.  This specialized connective tissue is basically liquid or gel-like and it’s called the blood.  Yes, that’s right; even though it’s rarely thought of as such, the blood is a (connective) tissue.
Almost all health challenges, including arthritis, vasculitis, cellulitis and heart disease have a connective tissue connection.  CT is home to cells of the immune system, so connective tissue is often a target of autoimmune disease.  And because of its role in supporting the body, the classic wrinkling, shrinking and shriveling effects of old age as well as bone and muscle weakness and fragility are all likely to occur as blast cells slow down the connective tissue matrix degenerates.
Because of the relationship between connective tissue and the appearance of aging, collagen and other CT structures are often the target of advertising and marketing claims for various anti-aging and beauty aids such as skin firming products and wrinkle creams and cellulite wraps.  Yet unbeknownst to consumers who spend billions of dollars a year on such potions and lotions and pills in a largely futile attempt to restore a youthful appearance , the key to staying and looking young, vital  and healthy is to make sure connective tissue cells are being fed, oxygenated and kept free of toxicity.  Below are my Top 12 strategies and tools for building strong connective tissue.
#1 Vitamin C 1000-5000mg a day – the key that turns on the production collagen fibers the strongest most connective tissue substance and responsible for its  steel like tensile strength.
#2 Glycine (1-2 grams a day)  – the primary amino acid in connective tissue, glycine provides  the firmness of CT.  While not essential (the body makes its own glycine) increasing intake through diet and supplementation can assure a steady supply.  Whey protein is a great source of glycine.  And straight glycine supplements are also easily available via health store or the internet.
#3 Hyaluronic acid (100-200mg a day) – this under-appreciated complex sugar molecule contributes to detoxification and provides building blocks for healing soothing and growth and repair of connective tissue.
#4 Sulfur (MSM1000-3000mg a day) provides key support structure element for connective tissue.  As nutritional content and consumption of sulfur veggies (onions, garlic, shallots, broccoli, cauliflower) containing declined rates of osteoporosis increased.
#5 Creatine Monohydrate (1 teaspoonful 3 or 4 times week, after workouts) – tripeptide (3 amino acids) that support blast energy and structure of bone and connective tissue.
#6 Gelatin (1 teaspoonful to 1 tablespoonful in 8 oz. of water once a day- source of connective tissue building amino acids.  Soothes digestive tract inflammation for improved absorption of nutrients.
#7 Eat protein (at least ½ gram per day per pound of body weight)– connective tissue is made up mostly of protein.  Eating enough protein assures a constant supply of these amino acids.  Look for sulfur containing protein (meat seafood, whey, egg).  Dairy and egg protein also supply growth factors which can stimulate the production of a thick robust CT.
#8 Bone soup –this delicious traditional food is a spectacular immune booster (Jewish penicillin) and it’s glycine and protein  content are substantial easy to absorb.  Eat liberally, look for the recipe on pharmacistben.com.
#9 Practice deep breathing techniques – Healthy oxygenation slows down secretion of bone busting cortisol and improves energy production.  Lung muscles also propel lymphatic fluid promoting detoxification.
#10 Exercise – acute physical stress and weight bearing pressure stimulate blast cells production.
#11 Stay away from pro-inflammatory foods –This includes processed foods and refined sugar but food allergens including beans and veggies can all have anti bone building effects too. Inflammation promotes degeneration and slows down anabolic (building) activity of blast cells.
#12 Correct digestive health issues – minerals like calcium, magnesium and zinc and protein all key players is connective tissue health require healthy digestive functioning.  Taking bile salts, digestive enzymes and apple cider vinegar with meals can improve absorption of connective tissue building nutrients.
    Raisin bread is a bread that contains raisins. Its invention has been attributed to Henry David Thoreau. It is often classified as a sweet bread and is sometimes combined with cinnamon sugar. Served toasted or as a dessert, the bread is commonly found in the United States, Northern Europe, Germany and Australia. [Read more: From Wikipedia]
About the author, Ben Fuchs
I'm Ben Fuchs, a nutritional pharmacist from Boulder CO. I specialize in using nutritional supplements where other healthcare practitioners use toxic pharmaceutical drugs. I look at the human body as a healing & regenerating system, designed divinely to heal & renew itself on a moment to moment basis. "Take charge of your biochemistry through foods and supplements, rather than allow toxic prescription drugs to take charge of you."